Your browser doesn't support javascript.
loading
Assay of protein S in systemic lupus erythematosus.
Lawrie, A S; Lloyd, M E; Mohamed, F; Irons, S; Hughes, G R; Savidge, G F.
Afiliación
  • Lawrie AS; Haemophilia Centre, St Thomas' Hospital, Guy's and St Thomas' NHS Trust, London, UK.
Blood Coagul Fibrinolysis ; 6(4): 322-4, 1995 Jun.
Article en En | MEDLINE | ID: mdl-7548680
Free protein S:Ag and protein S activity determined by clotting assay are often regarded as synonymous; however, in the study group of patients, abnormal protein S activity (PS:Act) results correlated poorly with abnormal free (PS:Ag(r2 = 0.164). Significantly none of the patients in whom lupus anticoagulant and low free protein S:Ag were detected were found to have low PS:Act. These results could not be explained by activated protein C resistance, suggesting that lupus anticoagulant may cause prolongation of the clotting time within the PS:Act assay and thus give falsely high results. As reduced levels of free protein S:Ag and/or protein S activity are considered risk factors of thrombosis in systemic lupus erythematosus, these findings question the suitability of the protein S activity assay for patients who may have phospholipid antibodies.
Asunto(s)
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína S / Lupus Eritematoso Sistémico Tipo de estudio: Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Blood Coagul Fibrinolysis Asunto de la revista: ANGIOLOGIA / HEMATOLOGIA Año: 1995 Tipo del documento: Article Pais de publicación: Reino Unido
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína S / Lupus Eritematoso Sistémico Tipo de estudio: Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Blood Coagul Fibrinolysis Asunto de la revista: ANGIOLOGIA / HEMATOLOGIA Año: 1995 Tipo del documento: Article Pais de publicación: Reino Unido