Lipid peroxidation of erythrocytes during anemia of the hamsters infected with Leishmania donovani.
Mol Cell Biochem
; 146(2): 99-105, 1995 May 24.
Article
en En
| MEDLINE
| ID: mdl-7565650
ABSTRACT
Visceral leishmaniasis has been found to be associated with severe anemia and premature lysis of erythrocytes. Peroxidative damage of red cells has been noted in several hemolytic anemias. Present study shows enhanced formation of methemoglobin in hamsters infected with Leishmania donovani. Increased formation of malonyldialdehyde and diene conjugate has been noted in the erythrocytes of the infected animals with the progress of anemia. Results showed decreased activities of protective enzymes like superoxide dismutase, catalase and glutathione reductase against peroxidative attack. An increase in the membrane cholesterol/phospholipid ratio and a decrease in membrane fluidity of erythrocytes were observed under the diseased condition. Densitometric scan after SDS-PAGE of red cell membrane of the infected animals revealed significant degradation of band 3 and band 4.1 proteins. The results suggest that alteration in the membrane may lead to reduced life span of the red cells in experimental visceral leishmaniasis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leishmania donovani
/
Peroxidación de Lípido
/
Eritrocitos
/
Anemia
/
Leishmaniasis Visceral
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Mol Cell Biochem
Año:
1995
Tipo del documento:
Article