Cytologic diagnosis of ductal versus lobular carcinoma of the breast.
Acta Cytol
; 39(5): 865-9, 1995.
Article
en En
| MEDLINE
| ID: mdl-7571961
ABSTRACT
OBJECTIVE:
To determine the value of cytology in the differential diagnosis of ductal versus lobular carcinoma of the breast. STUDYDESIGN:
In this study we examined 11 cytologic parameters in fine needle aspiration (FNA) cytology specimens from 52 patients who underwent surgery and had subsequent histologic diagnoses. Eighty-eight percent (46 cases) were infiltrating ductal carcinoma, and 12% (6 cases) were invasive lobular carcinoma.RESULTS:
Of the 11 cytologic parameters only chromatin pattern (P < .0001), nuclear size (P < .004) and overall cell size (P < .004) showed statistically significant differences between the two groups. Nuclear chromatin was coarsely granular only in cases of ductal carcinoma, while fine granularity could be seen in both ductal and lobular tumors. An automated morphometric system was used to determine the nuclear and overall cell size. The granularity of nuclear chromatin in ductal carcinoma cells did not correlate significantly with nuclear and overall cell size; therefore, they should be considered independent cytologic parameters.CONCLUSION:
The cytologic differential diagnosis of ductal versus lobular carcinoma is difficult; based on this study, the presence of coarsely granular chromatin, nuclear size > 44 microns2 and cell size > 82 microns2 are the only features diagnostic of ductal versus lobular carcinoma.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Biopsia con Aguja
/
Neoplasias de la Mama
/
Carcinoma Lobular
/
Carcinoma Ductal de Mama
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Acta Cytol
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos