Effects of lacidipine and nifedipine on lower limb veins in nonphlebopathic patients.
J Cardiovasc Pharmacol
; 23 Suppl 5: S111-2, 1994.
Article
en En
| MEDLINE
| ID: mdl-7609497
ABSTRACT
The aim of this study was to evaluate the effect of lacidipine and nifedipine on lower limb veins. Forty hypertensive patients, aged 30-50 years, with no deep venous thrombosis, venous insufficiency, or hypothyroidism underwent double-blind treatment with placebo (1 week), lacidipine 4 mg once daily (1 week), and slow-release nifedipine 20 mg twice daily (1 week) in randomized sequence. Echo-color Doppler examination of superficial, deep, communicating, and perforating veins of the legs was performed. The results showed venous insufficiency and hypertension after 1-week administration of lacidipine (5 and 15%, respectively) and nifedipine (10 and 25%, respectively) and only two cases (5%) of venous hypertension during placebo administration. Lower limb edema was observed in two patients (5%) during treatment with nifedipine slow-release (SR). The hemodynamic effects of lacidipine and nifedipine were reversible but may contribute to the mechanism of lower limb edema.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dihidropiridinas
/
Bloqueadores de los Canales de Calcio
/
Nifedipino
/
Pierna
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Cardiovasc Pharmacol
Año:
1994
Tipo del documento:
Article
País de afiliación:
Italia