Inhibition of pulmonary eosinophilia and hyperreactivity by antibodies to interleukin-5.
Int Arch Allergy Immunol
; 107(1-3): 321-2, 1995.
Article
en En
| MEDLINE
| ID: mdl-7613159
ABSTRACT
Eosinophils infiltrate into the lungs during asthma and may cause the damage associated with pulmonary inflammation. In allergic animal models, antibodies to interleukin (IL)-5 inhibit pulmonary eosinophilia, tissue damage and hyperreactivity. Sch 55700, a humanized antibody against human IL-5, inhibits eosinophilia in these models with an extended biological duration. On the basis of this dosing regimen and the humanized nature of Sch 55700, it is anticipated that the host response leading to tolerance would be minimized.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Interleucina-5
/
Hiperreactividad Bronquial
/
Eosinofilia
/
Enfermedades Pulmonares
/
Anticuerpos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Int Arch Allergy Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos