CD40 ligand is functionally expressed on human eosinophils.
Eur J Immunol
; 25(3): 863-5, 1995 Mar.
Article
en En
| MEDLINE
| ID: mdl-7705419
ABSTRACT
CD40 ligand (CD40L), a surface molecule which can be expressed by T cells, mast cells and basophils, has been shown to be involved in the control of B cell proliferation, immunoglobulin class switching as well as in the activation of monocytes and T cells. We demonstrate that CD40L can also be expressed constitutively by eosinophils from an hypereosinophilic patient or, upon activation, by the eosinophilic cell line EOL-3 and normal blood eosinophils. Eosinophils were able to induce, in conjunction with IL-4, CD40L-dependent B cell proliferation in vitro. These results suggest that CD40L could play a role in the inflammatory processes during which eosinophil infiltration and activation are observed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glicoproteínas de Membrana
/
Eosinófilos
Límite:
Humans
Idioma:
En
Revista:
Eur J Immunol
Año:
1995
Tipo del documento:
Article
País de afiliación:
Suiza