N-acetylaspartate and N-acetylaspartylglutamate levels in Alzheimer's disease post-mortem brain tissue.
J Neurol Sci
; 127(2): 230-3, 1994 Dec 20.
Article
en En
| MEDLINE
| ID: mdl-7707082
ABSTRACT
The tissue concentrations of two related amino acid derivatives, N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) were determined in autopsy hippocampus, amygdala, cerebellar cortex and olfactory bulb of Alzheimer's disease patients and age-matched non-demented controls, using reverse-phase HPLC and fluorescence detection after precolumn derivatisation with the fluorophore 2-aminoanthracene. In Alzheimer's disease, NAA and NAAG concentrations were significantly reduced in the hippocampus (by 38 and 24%) and the amygdala (by 28 and 22%), but not in the olfactory bulb and the cerebellar cortex. These results indicate that the concentrations of NAA and NAAG are selectively decreased in brain areas affected by pathology in Alzheimer's disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Química Encefálica
/
Ácido Aspártico
/
Dipéptidos
/
Enfermedad de Alzheimer
/
Antagonistas de los Receptores Histamínicos H1
Límite:
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Neurol Sci
Año:
1994
Tipo del documento:
Article
País de afiliación:
Países Bajos