Effect of monensin on the invasiveness and multiplication of Legionella pneumophila.
J Med Microbiol
; 42(4): 269-75, 1995 Apr.
Article
en En
| MEDLINE
| ID: mdl-7707335
ABSTRACT
The polyether antibiotic monensin exhibited bacteriostatic activity against a clinical isolate of Legionella pneumophila in vitro. Experiments designed to test the effect of the compound on the invasiveness and multiplication of L. pneumophila in HeLa cells showed that, in the presence of the antibiotic, legionellas that penetrated the cells did not multiply. However, monensin did not alter the characteristics of phagosomes that contained ingested legionellas. In the presence of monensin, infected cells exhibited extensive vacuolation and a noticeable reduction in the number of intracellular micro-organisms was evident a few hours after infection.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Monensina
/
Legionella pneumophila
Límite:
Humans
Idioma:
En
Revista:
J Med Microbiol
Año:
1995
Tipo del documento:
Article
País de afiliación:
Italia