Renin inhibitor SC-51106 complexed with human renin: discovery of a new binding site adjacent to P3.
Bioorg Med Chem
; 2(9): 909-18, 1994 Sep.
Article
en En
| MEDLINE
| ID: mdl-7712126
ABSTRACT
SC-51106, a 'minimal-size' diol-based renin inhibitor lacking a P4 residue, has been co-crystallized with human renin and the structure of the complex determined by X-ray crystallography. This study defines the mode of binding of this important class of renin inhibitor, and in conjunction with molecular modeling, has led to the discovery of a new binding site adjacent to S3, which is termed the 'S3aux(iliary)' subsite.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Renina
/
Histidina
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
1994
Tipo del documento:
Article