[Quantitative analysis of cellular morphometry and DNA content measurement of experimental lung adenocarcinoma].

ABSTRACT

This article reported the image analysis of normal epithelia of bronchi (group 1), hyperplasia epithelia (group 2), atypical hyperplasia epithelia (group 3) and adenocarcinoma (group 4) of the lung in the hamsters induced by tin mine dust and chimney dust in Yunnan Tin Min CO. 16 parameters were observed and compared. Each value was tested by stepwise discriminational classification and an accuracy rate of 95% was reached. DNA ploidy was investigated, and no case of > 5C cell was found in normal and hyperplasia group. Severe atypia had a lower percentage, (4.00%) and lung adenocarcinoma was characterized by a high percentage of > 5C cell (10.75%), A significant difference was shown between the percentage of > 5C cell of severe atypia and that of adenocarcinoma. Significantly different (P < 0.01).