Identification of polymorphisms in the constant region of IgG3: the missing mouse allotype.
Int Immunol
; 7(2): 337-41, 1995 Feb.
Article
en En
| MEDLINE
| ID: mdl-7734427
ABSTRACT
We have identified DNA sequence polymorphisms in the C gamma 3 genes of BALB/c and C57BL/6 mice. One of these results in a Ser-->Gly amino acid difference in CH1 at position 129 according to the Wu and Kabat numbering system. There are three additional silent substitutions in the coding region and two polymorphic nucleotides in the 3' untranslated region. According to standard nomenclature in which alleles are numbered according to the order of their identification, these C gamma 3 alleles are designated Igh-8a and Igh-8b respectively. We also describe two polymerase chain reaction-based assays that identify the allelic differences.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Inmunoglobulina G
/
Regiones Constantes de Inmunoglobulina
/
Alotipos de Inmunoglobulinas
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Int Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos