Antibiotic penetration of experimental intra-abdominal abscesses.
Am Surg
; 61(6): 521-5, 1995 Jun.
Article
en En
| MEDLINE
| ID: mdl-7762902
ABSTRACT
Intra-abdominal abscess is seldom adequately treated by systemic antibiotics alone and often requires surgical or computed tomography-guided drainage for resolution. Abscess penetration of six currently used antibiotics was examined in a murine intra-abdominal abscess model. Ampicillin/sulbactam, cefmetazole, clindamycin, and trospectomycin penetrated intra-abdominal abscesses to a greater degree than cefoxitin and ceftriaxone. Abscess pus antibiotic levels were not significantly higher after multiple doses than after a single dose. Pus antibiotic levels below the MIC90 for Bacteroides and E. coli within intra-abdominal abscess were observed for most antibiotics with the doses used in this study. Selection of antibiotics with a greater ability to penetrate abscess may be important in optimally treating patients with abdominal infection.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Absceso Abdominal
/
Antibacterianos
Idioma:
En
Revista:
Am Surg
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos