Chronic mineralocorticoid excess and cardiovascular remodeling.
Steroids
; 60(1): 125-32, 1995 Jan.
Article
en En
| MEDLINE
| ID: mdl-7792797
ABSTRACT
Chronic mineralocorticoid (MC) excess, whether due to elevated plasma aldosterone (ALDO) or deoxycorticosterone (DOC), is associated with a perivascular fibrosis of systemic and coronary arterioles. This remodeling of resistance vessels contributes to the appearance of hypertension. Chronic MC excess is also accompanied by cardiac myocyte necrosis, secondary to myocardial potassium depletion, and a subsequent reparative fibrosis that appears in the normotensive, nonhypertrophied right and hypertensive, hypertrophied left ventricles. Fibrosis contributes to the appearance of ventricular arrhythmias and dysfunction. Herein, clinical and experimental evidence linking chronic, inappropriate (relative to dietary sodium) elevations in circulating ALDO and DOC with these reactive and reparative forms of fibrous tissue formation in the heart and other tissues is presented.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glándulas Suprarrenales
/
Hiperplasia Suprarrenal Congénita
/
Desoxicorticosterona
/
Aldosterona
/
Fibrosis Endomiocárdica
/
Mineralocorticoides
Límite:
Adult
/
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Steroids
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos