Bilateral herpes simplex virus type 2 keratitis: a clinicopathologic report with immunohistochemical and ultrastructural observations.
Ger J Ophthalmol
; 4(2): 116-22, 1995 Mar.
Article
en En
| MEDLINE
| ID: mdl-7795510
ABSTRACT
This report describes the clinical, histopathologic, ultrastructural, and immunohistochemical findings in two corneal buttons from a 13-year-old girl who developed bilateral progressive corneal stromal opacification during childhood. As determined by light microscopy, both corneal buttons were edematous with a chronic inflammatory infiltrate confined to the deep layers of the stroma. We detected intranuclear eosinophilic inclusions in some epithelial cells. We detected herpesvirus particles in stromal keratocytes and endothelial cells by transmission electron microscopy. Immunohistochemistry studies identified concurrent expression of specific herpes simplex virus type 2 antigen in corneal epithelial cells, in keratocytes in the deep layers of the stroma, and in endothelial cells. The cause of progressive bilateral stromal corneal opacification in this child was herpes simplex virus type 2 keratitis. This condition should be considered in the differential diagnosis of progressive, bilateral corneal opacification in children.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Queratitis Herpética
/
Herpesvirus Humano 2
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
/
Female
/
Humans
Idioma:
En
Revista:
Ger J Ophthalmol
Asunto de la revista:
OFTALMOLOGIA
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos