Direct imaging of molecular transport through skin.
J Invest Dermatol
; 104(1): 142-5, 1995 Jan.
Article
en En
| MEDLINE
| ID: mdl-7798633
ABSTRACT
Scanning electrochemical microscopy (SECM) was used to image spatial variations in the molecular flux of Fe(CN)6(-4) across excised hairless and nude mouse skin. The SECM response is specific to electroactive molecules, allowing selective imaging of the flux of Fe(CN)6(-4) in multicomponent ionic solutions. Quantitative SECM image analysis demonstrated that 40% to 60% of the total Fe(CN)6(-4) flux occurred through appendages in the skin. SECM analysis of skin samples exposed to a known transport enhancer, sodium dodecylsulfate, indicated that the increase in the ion transport rate occurred exclusively in nonporous skin tissue.
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MEDLINE
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Piel
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Ferrocianuros
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Animals
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En
Revista:
J Invest Dermatol
Año:
1995
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Article