Characterization of bile ducts in primary biliary cirrhosis and other liver diseases by immunohistochemical demonstration of Lewis(a) or b antigen.
Zentralbl Pathol
; 140(4-5): 299-307, 1994 Nov.
Article
en En
| MEDLINE
| ID: mdl-7826978
We investigated Lewis(a) and Lewis(b) expression of bile ducts in 68 specimens from various kinds of liver disease. In addition, the number of IgM and IgG synthesizing plasma cells in the hepatic inflammatory reactions were immunostained and counted. We found a statistically significant decrease in the number of bile ducts in PBC (primary biliary cirrhosis) in comparison with either chronic active or persistent hepatitis (CAH/CPH). Bile ducts could be detected easily and constantly by their Lewis antigen expression. Isolated bile duct epithelial cells not apparent in H&E sections could be identified by Lewis(a) and b immunostaining. The number of plasma cells in PBC was significantly different than in (CAH/CPH). A large number of IgM plasma cells was a characteristic feature of PBC. However, neither counting of Lewis(a) and b positive bile ducts nor counting of IgM plasma cells was of definite diagnostic significance in the individual clinical case, since no cut-off value could be determined above or below which a PBC was ruled out or proven.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Conductos Biliares
/
Hepatitis
/
Antígenos del Grupo Sanguíneo de Lewis
/
Hígado
/
Cirrosis Hepática Biliar
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Zentralbl Pathol
Asunto de la revista:
PATOLOGIA
Año:
1994
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Alemania