Anti-invasive activity of 3,7-dimethoxyflavone in vitro.
J Pharm Sci
; 83(9): 1217-21, 1994 Sep.
Article
en En
| MEDLINE
| ID: mdl-7830234
ABSTRACT
Invasion of MCF-7/6 human mammary carcinoma cells into embryonic chick heart fragments was studied in organ culture during 8 days. The effect of 31 polyphenolic compounds, belonging to the flavonoids, chalcones, or coumarins, was tested in this assay for invasion. The anti-invasive activity of 3,7-dimethoxyflavone was found at concentrations ranging from 1 to 100 microM. At these anti-invasive concentrations, no cytotoxic effects could be detected the anti-invasive effect was reversible upon omission of the molecule from the medium, and treatment of MCF-7/6 cells or heart fragments did not affect subsequent outgrowth from explants on tissue culture plastic. The molecule did not inhibit growth of MCF-7/6 cell aggregates nor of heart fragments kept in suspension culture. The action mechanism of 3,7-dimethoxyflavone is the subject of our ongoing research.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Flavonoides
/
Invasividad Neoplásica
/
Antineoplásicos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Pharm Sci
Año:
1994
Tipo del documento:
Article
País de afiliación:
India