Effect of glucose administration on the blood sugar and pancreatic islets of the frog, Rana tigrina.
Acta Anat (Basel)
; 94(1): 30-9, 1976.
Article
en En
| MEDLINE
| ID: mdl-785932
ABSTRACT
Glucose evoked significant hyperglycemia in the frog, Rana tigrina, 0.5 h after the injection and it took a longer time to regain normoglycemia than mammals, thus exhibiting a low glucose tolerance. The islet tissue of injected animals showed degranulation and atrophy of beta-cells only, the alpha-cells remained almost normal. This damage suggests that the beta-cells of this frog are functionally like those of mammals and other vertebrates, and secrete insulin. A single dose of glucose was found incapable of producing permanent diabetes, and beta-cells damage was repairable at later stages. Excess of glucose in the blood seems to stimulate secretion of insulin by the beta-cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glucemia
/
Islotes Pancreáticos
/
Prueba de Tolerancia a la Glucosa
Límite:
Animals
Idioma:
En
Revista:
Acta Anat (Basel)
Año:
1976
Tipo del documento:
Article