Susceptibility to alloimmunization to platelet HPA-1a antigen involves TAP1 polymorphism.
Hum Immunol
; 41(2): 141-5, 1994 Oct.
Article
en En
| MEDLINE
| ID: mdl-7860359
ABSTRACT
The alloimmunization against platelet HPA-1a antigen in mothers of thrombocytopenic neonates is strongly associated with HLA class II structures (DR3 and DR13) and especially with HLA-DR52a antigen (98% of the cases reported here). Because new genes have recently been mapped within the MHC class II region, we typed TAP1 and TAP2 gene polymorphisms by ARMS-PCR in order to characterize more effectively MHC genes involved in this alloimmunization. Our results showed that TAP1*0102 allele was significantly associated with NAIT only in the population of HLA-DR 13-DR52a-immunized women (50%) versus HLA-DR 13-DR52a controls (20%) (p < 0.05), and not in HLA-DR3-DR52a-immunized women versus HLA-DR3-DR52a controls. There is no linkage disequilibrium between TAP1*0102 and DRB1*13 alleles (delta = -0.0063) that could account for this result. The higher frequency of TAP1*0102 allele among HLA-DR 13-DR52a-immunized women suggests that HPA-1a antigen presentation and recognition may be influenced by nonclassic HLA class II gene polymorphisms, or that other linked but yet unknown genes could interfere.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Trombocitopenia
/
Antígenos HLA-D
/
Antígenos de Plaqueta Humana
/
Transportadoras de Casetes de Unión a ATP
Límite:
Female
/
Humans
/
Newborn
Idioma:
En
Revista:
Hum Immunol
Año:
1994
Tipo del documento:
Article
País de afiliación:
Francia