Effect of sulglycotide in the prevention of duodenal ulcer relapse.
Eur J Gastroenterol Hepatol
; 7(1): 25-8, 1995 Jan.
Article
en En
| MEDLINE
| ID: mdl-7866806
ABSTRACT
OBJECTIVE:
To evaluate the effectiveness of sulglycotide, a gastroprotective drug, as maintenance treatment for patients with duodenal ulcer.DESIGN:
A randomized double-blind study.METHODS:
A total of 119 patients with recently healed duodenal ulcers were randomly allocated, in a double-blind fashion, to receive sulglycotide 200 mg twice daily (60 patients) or placebo (59 patients) for 1 year. Patients underwent clinical assessment every third month and endoscopy at 6 and 12 months, or earlier if relapse was suspected.RESULTS:
The cumulative endoscopic relapse rates, compared using the log rank test, were 37 and 52% after 6 and 12 months, respectively, in the sulglycotide group and 62 and 71% (P = 0.03), respectively, in the placebo group.CONCLUSIONS:
Sulglycotide is moderately effective as a maintenance treatment for duodenal ulcer disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sialoglicoproteínas
/
Úlcera Duodenal
/
Antiulcerosos
Tipo de estudio:
Clinical_trials
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur J Gastroenterol Hepatol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
1995
Tipo del documento:
Article
País de afiliación:
Italia