Modulation of renal osteodystrophy by extrarenal production of calcitriol.
Am J Nephrol
; 15(1): 85-9, 1995.
Article
en En
| MEDLINE
| ID: mdl-7872371
ABSTRACT
We report a patient with severe chronic renal failure who developed spontaneous bone fractures. He was found to have hypercalcemia, normal calcitriol levels (probably due to extrarenal production by noncaseating granulomas), and functional hypoparathyroidism. The bone biopsy showed low bone turn-over and the presence of noncaseating granulomas. Treatment with corticosteroids decreased the calcium and calcitriol levels and the parathyroid hormone levels rose. No further fractures occurred. A repeat bone biopsy revealed the presence of osteitis fibrosa. Renal osteodystrophy may be modulated by extrarenal production of calcitriol. In this case, excessive suppression of parathyroid hormone by endogenous calcitriol presumably caused an adynamic bone lesion and spontaneous fractures.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastorno Mineral y Óseo Asociado a la Enfermedad Renal Crónica
/
Calcitriol
/
Fracturas del Fémur
/
Fracturas Espontáneas
/
Fallo Renal Crónico
Tipo de estudio:
Etiology_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Am J Nephrol
Año:
1995
Tipo del documento:
Article