A trial of a group A plus group C meningococcal polysaccharide-protein conjugate vaccine in African infants.
J Infect Dis
; 171(3): 632-8, 1995 Mar.
Article
en En
| MEDLINE
| ID: mdl-7876610
ABSTRACT
The safety and immunogenicity of a group A plus group C meningococcal polysaccharide-CRM197 conjugate vaccine was evaluated in 304 8- to 10-week-old Gambian infants. Infants were immunized with one, two, or three doses of conjugate vaccine or with two doses of a meningococcal A plus C polysaccharide vaccine. The conjugate vaccine produced few systemic side effects, and local reactions were similar to those produced by the polysaccharide vaccine. Postvaccination group A meningococcal polysaccharide antibody levels, measured by ELISA, increased progressively after one, two, or three doses of conjugate vaccine. However, one dose of conjugate vaccine given at the age of 6 months induced a higher group C meningococcal antibody response than did two doses of conjugate vaccine given at 2 and 6 months. Two doses of conjugate vaccine induced higher levels of antibody than did two doses of polysaccharide vaccine. Thus, this new meningococcal conjugate vaccine proved to be safe and immunogenic.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polisacáridos Bacterianos
/
Proteínas Bacterianas
/
Vacunas Bacterianas
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Neisseria meningitidis
Tipo de estudio:
Clinical_trials
Límite:
Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
J Infect Dis
Año:
1995
Tipo del documento:
Article