Endogenous complement C3 synthesis in immune complex nephritis.
Lancet
; 342(8882): 1273-4, 1993 Nov 20.
Article
en En
| MEDLINE
| ID: mdl-7901586
ABSTRACT
Human renal epithelial and mesangial cells have been shown to synthesise complement C3 in culture, but the relevance of this finding to the development of complement-mediated nephritis is uncertain. We investigated C3 gene expression in tissue biopsies that showed three main categories of renal injury. By semiquantitative polymerase chain reaction, biopsies from patients with immune-complex glomerulonephritis and those with cell-mediated interstitial nephritis showed increased C3 expression (p < 0.05), but biopsies from patients with non-immune glomerular injury did not. These findings suggest that local C3 production is enhanced in immune-mediated nephritis and are consistent with the hypothesis that locally synthesised complement components are involved in the pathogenesis of tissue injury.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Complemento C3c
/
Enfermedades del Complejo Inmune
/
Corteza Renal
/
Nefritis
Límite:
Humans
Idioma:
En
Revista:
Lancet
Año:
1993
Tipo del documento:
Article
País de afiliación:
Reino Unido