[Proliferative activity of peripheral blood lymphocytes and evaluation of the effectiveness of drugs in lichen ruber planus]. / Proliferativnaia aktivnost' limfotsitov perifericheskoi krovi i otsenka éffektivnosti lekarstvennykh preparatov pri krasnom ploskom lishae.

ABSTRACT

A total of 106 patients with lichen planus were examined for proliferative activity of peripheral blood lymphocytes and exogenous interleukin-2 effect on recovery of cyclosporin A suppressed proliferative response to mitogen. Lymphocyte proliferative activity was assessed by the level of 3H thymidine incorporation in cellular DNA. This parameter was found reduced in patients with lichen planus in comparison with healthy donors and dependent on the disease stage but not degree of dissemination. No disorders were detected in lymphocyte capacity to express receptors for interleukin-2 in the course of their activation. Tigason, prednisolone, and delagil had a marked in vitro antiproliferative effect on the lymphocytes of patients with lichen planus, tigason exerting the highest effect and prednisolone the lowest.