Cobalt myocardiopathy. A critical review of literature.
Sci Total Environ
; 150(1-3): 105-9, 1994 Jun 30.
Article
en En
| MEDLINE
| ID: mdl-7939581
ABSTRACT
Cobalt is regarded as being responsible for a form of myocardiopathy whose pathogenesis and clinical description must still find a specific place in the range of congestive myocardiopathies. In spite of this, epidemiological studies are not sufficient to prove the role of cobalt in inducing myocardiopathy in hard metal workers. This critical review intends to evaluate if hard metal exposure may induce toxic effects on the heart. In this context, the literature considered ranges from pioneer reports on 'beer drinkers' to the more recent papers concerning cases of patients occupationally exposed; subjects who, after a surgical operation died of fulminant heart failure and, lastly, hard metal workers who were examined for their cardiac function. Various pathogenetic mechanisms related to possible cardiac effects in hard metal workers have been analyzed. The most likely should be the inhibition of cellular respiration due to inhibition of the mitochondrial dehydrogenase.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cobalto
/
Cardiomiopatías
Límite:
Humans
Idioma:
En
Revista:
Sci Total Environ
Año:
1994
Tipo del documento:
Article
País de afiliación:
Italia