[Interaction of 1-O-alkyl-2-methoxy-sn-glycero-3-phosphocholine and platelet activating factor with blood and tumor cells]. / Vzaimodeistvie 1-O-alkil-2-metoksi-sn-glitsero-3-fosfokholina i faktora aktivatsii trombotsitov s kletkami krovi i opukholevymi kletkami.
Biokhimiia
; 59(7): 1054-61, 1994 Jul.
Article
en Ru
| MEDLINE
| ID: mdl-7948414
ABSTRACT
The effects of the platelet-activating factor (PAF) and the methoxy-PAF analog, 1-O-alkyl-2-methoxy-sn-glycero-3-phosphocholine, on platelet activation, oxidative burst in neutrophils and proliferation of K-562 and P815 cells have been studied. It has been found that the biological activity of methoxy-PAF for human platelets and neutrophils is commensurate with that of PAF. However, the cytotoxic properties of methoxy-PAF are much stronger than the cytotoxicity of PAF for tumour cells. It is concluded that the biological activity of methoxy-PAF is, to a great extent, due to its close structural resemblance to PAF as well as to the inability of cells to perform rapid metabolism of methoxy-PAF.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosfatidilcolinas
/
Factor de Activación Plaquetaria
/
Neutrófilos
Límite:
Animals
/
Humans
Idioma:
Ru
Revista:
Biokhimiia
Año:
1994
Tipo del documento:
Article