Comparative study of the action of flunixin meglumine and tolfenamic acid on prostaglandin E2 synthesis in bovine inflammatory exudate.
J Vet Pharmacol Ther
; 17(4): 271-4, 1994 Aug.
Article
en En
| MEDLINE
| ID: mdl-7966545
ABSTRACT
An acute non-immune inflammation model was used to compare the action of two non-steroidal anti-inflammatory drugs, flunixin meglumine and tolfenamic acid, on prostaglandin E2 (PGE2) synthesis in bovine inflammatory exudate. The tissue cage model used involves subcutaneous implantation of polypropylene cages and subsequent stimulation by carrageenan injection of the granulation tissue which develops within the cage. Twelve calves were randomly assigned to three groups receiving placebo, flunixin meglumine and tolfenamic acid, respectively. Inflammatory exudate was sampled 30 min after carrageenan injection and at seven subsequent time points. PGE2 levels were determined by radioimmunoassay. At each time point post-carrageenan injection, flunixin meglumine inhibited PGE2 synthesis to a greater extent than tolfenamic acid. At 4, 8, 12 and 24 h these differences were statistically significant.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Clonixina
/
Dinoprostona
/
Antiinflamatorios no Esteroideos
/
Exudados y Transudados
/
Ortoaminobenzoatos
/
Inflamación
Límite:
Animals
Idioma:
En
Revista:
J Vet Pharmacol Ther
Año:
1994
Tipo del documento:
Article
País de afiliación:
Francia