A phase of liposomes with entangled tubular vesicles.
Science
; 266(5188): 1222-5, 1994 Nov 18.
Article
en En
| MEDLINE
| ID: mdl-7973704
ABSTRACT
An equilibrium phase belonging to the family of bilayer liposomes in ternary mixtures of dimyristoylphosphatidylcholine (DMPC), water, and geraniol (a biological alcohol derived from oil-soluble vitamins that acts as a cosurfactant) has been identified. Electron and optical microscopy reveal the phase, labeled Ltv, to be composed of highly entangled tubular vesicles. In situ x-ray diffraction confirms that the tubule walls are multilamellar with the lipids in the chain-melted state. Macroscopic observations show that the Ltv phase coexists with the well-known L4 phase of spherical vesicles and a bulk L alpha phase. However, the defining characteristic of the Ltv phase is the Weissenberg rod climbing effect under shear, which results from its polymer-like entangled microstructure.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Terpenos
/
Dimiristoilfosfatidilcolina
/
Membrana Dobles de Lípidos
/
Liposomas
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Science
Año:
1994
Tipo del documento:
Article