Susceptibility to adenosine agonists of giant migrating contraction induced by glycerol enema in anesthetized rats.
Jpn J Pharmacol
; 65(4): 361-5, 1994 Aug.
Article
en En
| MEDLINE
| ID: mdl-7990273
ABSTRACT
The present study examined whether adenosine agonists influence the occurrence of giant migrating contractions (GMCs) induced by glycerol enema (65%, 2 ml/kg) in rats. Catheter pressure transducers were used to measure the colonic luminal manometric alterations. The adenosine A1 agonists (2S)-N6-(2-endo-norbornyl)adenosine ((S)-ENBA) (10 micrograms/kg, i.v.) and N6-cyclohexyladenosine (30 micrograms/kg, i.v.) abolished the GMCs, whereas the adenosine A2 agonist 2-[p-(2-carboxyethyl)phenethylamino]-5'-N-ethylcarboxamidoadenosin e (CGS 21680) (30-300 micrograms/kg, i.v.) failed to influence the GMCs. The suppressive action of (S)-ENBA on the GMCs was entirely counteracted by the peripheral adenosine antagonist 8-(p-sulfophenyl)theophylline (10 mg/kg, i.v.). The present observations suggest that the adenosine A1 agonist suppresses the GMCs via peripheral adenosine receptors.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Adenosina
/
Colon
/
Motilidad Gastrointestinal
/
Glicerol
Límite:
Animals
Idioma:
En
Revista:
Jpn J Pharmacol
Año:
1994
Tipo del documento:
Article
País de afiliación:
Japón