Application of enzyme immunoassay for postchemotherapy evaluation of human strongyloidiasis.
Diagn Microbiol Infect Dis
; 18(1): 19-23, 1994 Jan.
Article
en En
| MEDLINE
| ID: mdl-8026153
ABSTRACT
Posttherapy evaluation of strongyloidiasis is frequently difficult because coprologic examination is not sensitive enough for diagnosis of chronic infection. In the present study, anti-Strongyloides enzyme-linked immunosorbent assay antibodies were monitored before and after treatment with thiabendazole and pyrvinium pamoate in 199 patients with chronic strongyloidiasis in Okinawa, Japan. A significant decrease in antibody levels was observed in patients who became negative for fecal larvae after the treatment, whereas the antibody levels did not show a significant change after the treatment in patients who were still harboring the parasite. In the group coprologically negative in the follow-up examination, however, many individuals did not show a significant fall in antibody titers after treatment, which suggests that these cases were equivocal for complete cure. By the subsequent fecal reexamination performed on the equivocal cases, approximately 20% were additionally found to be still harboring the parasite. These results indicate that serologic testing is useful to check whether a real cure has been achieved among the patients in whose fecal samples the presence of larvae has not been demonstrated after treatment.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estrongiloidiasis
/
Ensayo de Inmunoadsorción Enzimática
/
Anticuerpos Antihelmínticos
/
Strongyloides stercoralis
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Antihelmínticos
Límite:
Adult
/
Aged
/
Aged80
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Animals
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Diagn Microbiol Infect Dis
Año:
1994
Tipo del documento:
Article
País de afiliación:
Japón