Epstein-Barr virus-associated large granular lymphocyte leukemia with cutaneous infiltration.
J Am Acad Dermatol
; 31(2 Pt 1): 251-5, 1994 Aug.
Article
en En
| MEDLINE
| ID: mdl-8040410
ABSTRACT
A 36-year-old man had a high titer of antibody to Epstein-Barr virus (EBV) and recurrent necrotizing papules and nodules on his face and oral mucosa. The disease was diagnosed as CD3+4- 8+ large granular lymphocyte leukemia of T-cell origin. Southern blot analysis demonstrated that EBV DNA was present in CD8+ lymphocytes; EBV antigens were also observed in these lymphocytes. These findings demonstrated that EBV latently infected the leukemic cells and may have played a role in the pathogenesis of this disease. This is the first report of an association between EBV and large granular lymphocyte leukemia of T-cell origin.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piel
/
Infecciones Tumorales por Virus
/
Leucemia de Células T
/
Infiltración Leucémica
/
Herpesvirus Humano 4
/
Infecciones por Herpesviridae
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
J Am Acad Dermatol
Año:
1994
Tipo del documento:
Article
País de afiliación:
Japón