In vivo aspects of progesterone distribution and metabolism.
Am J Obstet Gynecol
; 123(5): 527-34, 1975 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-810027
ABSTRACT
The end-organ response of any hormone is the result of many factors which precede the event, including biosynthesis, secretion, transport, distribution, and metabolism. These factors vary among different species. The metabolic clearance rate (MCR) of progesterone varies between 40 and 180 L./day/Kg. in man (60 to 70), monkey (40 to 50), rabbit (55 to 60), sheep (110), rat (120), and guinea pig (180). Major sites of clearance include liver, brain, and uterus. Specific metabolites of progesterone include 20 alpha-hydroxypregn-4-en-3-one (20 alphaOHP) and alpha-pregnan-3,20-dione (5 alpha-DPH). Liver, brain, and uterine clearances, extractions, and conversions of progesterone to these metabolites have been studied in various species under apparent steady-state conditions. A specific hormone action of progesterone, the appearance of uteroglobin in the rabbit uterus, has also been studied in varying horomonal states (estrogen, estrogen plus progesterone, and progesterone alone). These have all been used as examples of progesterone distribution and metabolism.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Progesterona
/
Útero
/
Encéfalo
/
Hígado
Límite:
Animals
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Female
/
Humans
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Male
Idioma:
En
Revista:
Am J Obstet Gynecol
Año:
1975
Tipo del documento:
Article