[The sensitivity and specificity of the clinical, serological and tomographic diagnosis of Toxoplasma gondii encephalitis in the acquired immunodeficiency syndrome (AIDS)]. / Sensibilidade e especificidade do diagnóstico clínico, sorológico e tomográfico da encefalite por Toxoplasma gondii na síndrome da imunodeficiência adquirida (SIDA).
Rev Soc Bras Med Trop
; 26(2): 71-5, 1993.
Article
en Pt
| MEDLINE
| ID: mdl-8128073
ABSTRACT
Toxoplasmic encephalitis (TE) is among the most common neurologic affections and it is the most prevalent cause of intracerebral mass lesions in AIDS patients. All patients with AIDS hospitalized at the Hospital de Clínicas de Porto Alegre between May/85 and December/91 (516 cases) had their files revised to determinate TE prevalence, serology, sensitivity and specificity of the computed tomography (CT) brain scan, clinical findings and serology to make its diagnosis. The prevalence on CT was 13% (presumptive diagnosis). Blood serology and cerebrospinal (CSF) serology to toxoplasma were positive respectively in 65% and 49%. Autopsies of 125 patients were also revised with a prevalence of 22% (definite diagnosis). CT scan had 65% of sensitivity and 82% of specificity. Sensitivity and specificity of serology on blood was respectively 95% and 30%, while the cerebrospinal fluid (CSF) serology had 77% of sensitivity and 56% of specificity. The following clinical findings were considered fever (sensitivity = 92%; specificity = 56%), neurological focal signs (sensitivity = 59%; specificity = 82%) and headache (sensitivity = 41%; specificity = 69%). We conclude that, based on the high serology sensitivity and high CT scan specificity, they constitute an useful approach to make TE diagnosis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Toxoplasma
/
Anticuerpos Antiprotozoarios
/
Tomografía Computarizada por Rayos X
/
VIH-1
/
Toxoplasmosis Cerebral
/
Infecciones Oportunistas Relacionadas con el SIDA
/
Encefalitis
Tipo de estudio:
Diagnostic_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Animals
/
Female
/
Humans
/
Male
País/Región como asunto:
America do sul
/
Brasil
Idioma:
Pt
Revista:
Rev Soc Bras Med Trop
Año:
1993
Tipo del documento:
Article
País de afiliación:
Brasil