Description of Guanarito virus (Arenaviridae: Arenavirus), the etiologic agent of Venezuelan hemorrhagic fever.
Am J Trop Med Hyg
; 50(4): 452-9, 1994 Apr.
Article
en En
| MEDLINE
| ID: mdl-8166352
ABSTRACT
This paper characterizes Guanarito virus, the etiologic agent of Venezuelan hemorrhagic fever. Based on its morphology and antigenic properties, Guanarito virus appears to be a new member of the Tacaribe complex of the genus Arenavirus, family Arenaviridae. Complement fixation and indirect fluorescent antibody tests showed that Guanarito virus and its antiserum are broadly cross-reactive with other members of the Tacaribe complex, but it can be differentiated from other members of the complex by neutralization test. Guanarito virus causes mortality in suckling mice and adult guinea pigs, but not in adult mice. Inoculated rhesus monkeys developed viremia and became ill; however, they subsequently recovered and responded with production of antibody. To date, all isolates of Guanarito virus have come from sick persons or wild rodents living within a single geographic focus in the central plains of Venezuela.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arenavirus del Nuevo Mundo
/
Fiebre Hemorrágica Americana
Tipo de estudio:
Etiology_studies
Límite:
Adult
/
Animals
/
Humans
/
Male
País/Región como asunto:
America do sul
/
Venezuela
Idioma:
En
Revista:
Am J Trop Med Hyg
Año:
1994
Tipo del documento:
Article