Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q.
Science
; 264(5162): 1141-5, 1994 May 20.
Article
en En
| MEDLINE
| ID: mdl-8178173
ABSTRACT
A gene involved in psoriasis susceptibility was localized to the distal region of human chromosome 17q as a result of a genome-wide linkage analysis with polymorphic microsatellites and eight multiply affected psoriasis kindreds. In the family which showed the strongest evidence for linkage, the recombination fraction between a psoriasis susceptibility locus and D17S784 was 0.04 with a maximum two-point lod score of 5.33. There was also evidence for genetic heterogeneity and although none of the linked families showed any association with HLA-Cw6, two unlinked families showed weak levels of association. This study demonstrates that in some families, psoriasis susceptibility is due to variation at a single major genetic locus other than the human lymphocyte antigen locus.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Psoriasis
/
Cromosomas Humanos Par 17
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Science
Año:
1994
Tipo del documento:
Article