Amplification of N-myc gene and increase of urinary VMA and HVA in patients with neuroblastic tumors.
Nihon Ika Daigaku Zasshi
; 61(2): 148-53, 1994 Apr.
Article
en En
| MEDLINE
| ID: mdl-8195324
ABSTRACT
Neuroblastic tumor cases in our departments were evaluated in terms of the stage of the tumor, N-myc amplification, urinary vanillylamndelic acid (VMA)/homovanillic acid (HVA) and survival rate. Two asymptomatic cases, diagnosed when under a year old by mass screening, had no amplifications of N-myc but showed more than one value of urinary VMA/HVA ratio. The patients are now doing well eight years after complete excision of the neuroblastoma which had originated in the sympathetic ganglion. On the other hand, two other symptomatic cases, operated on at the ages of 3 and 5 years, showed remarkable amplifications with less than one value of urinary VMA/HVA, and died from the tumor soon after partial resection of the neuroblastoma and ganglioneuroblastoma which had originated in the adrenal gland and the sympathetic ganglion, respectively. The present monograph reports our cases and discusses prognostic factors.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácido Vanilmandélico
/
Genes myc
/
Ganglios Simpáticos
/
Ácido Homovanílico
/
Neoplasias del Sistema Nervioso
/
Neuroblastoma
Tipo de estudio:
Prognostic_studies
/
Screening_studies
Límite:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Nihon Ika Daigaku Zasshi
Año:
1994
Tipo del documento:
Article
País de afiliación:
Japón