An analysis of the humoral immune response of dogs following vaccination with irradiated infective larvae of Dirofilaria immitis.
Parasite Immunol
; 16(3): 157-64, 1994 Mar.
Article
en En
| MEDLINE
| ID: mdl-8208588
ABSTRACT
In this study, dogs were immunized with irradiated L3 larvae of Dirofilaria immitis. Following challenge with non-irradiated L3, vaccinated dogs had an average of 71% fewer adult worms compared to non-vaccinated animals. A comparative analysis of eosinophil and antibody responses of these two groups of dogs is presented. Vaccinated dogs preferentially recognized several larval (14, 20, 30, 34, 39 kDa), adult worm (20 kDa) and microfilarial (36, 38, 71, 84 kDa) antigens. To characterize these antigens, the extent of glycosylation was assessed. The data suggest that an earlier response to these antigens may be important in the protection induced in dogs by administration of irradiated L3 of D. immitis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Anticuerpos Antihelmínticos
/
Vacunación
/
Dirofilaria immitis
/
Dirofilariasis
/
Enfermedades de los Perros
Límite:
Animals
Idioma:
En
Revista:
Parasite Immunol
Año:
1994
Tipo del documento:
Article