Familial calcification of aorta and calcific aortic valve disease associated with immunologic abnormalities.
Am Heart J
; 126(4): 904-9, 1993 Oct.
Article
en En
| MEDLINE
| ID: mdl-8213448
ABSTRACT
We report three patients of the same family with linear calcification of the ascending aorta, severe calcific mixed aortic valve disease associated with increased levels of globulins, lambda-chain gammopathy, an increased T4/T8 lymphocyte ratio, and other immunologic abnormalities. None of the patients had syphilis, atherosclerosis, abnormalities of calcium or phosphorus metabolism, lymphadenopathy, or other systemic diseases. It is postulated that these cases and some previously reported in the literature as idiopathic represent a distinct pathologic entity, familial or sporadic, in which localized vascular and valvular calcific disease is associated with an underlying immunologic disorder or autoimmune process.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades de la Aorta
/
Insuficiencia de la Válvula Aórtica
/
Estenosis de la Válvula Aórtica
/
Calcinosis
/
Cadenas Ligeras de Inmunoglobulina
/
Hipergammaglobulinemia
Tipo de estudio:
Diagnostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am Heart J
Año:
1993
Tipo del documento:
Article
País de afiliación:
Grecia