Electron microscopic changes in Enterocytozoon bieneusi following treatment with albendazole.
J Clin Pathol
; 46(10): 898-902, 1993 Oct.
Article
en En
| MEDLINE
| ID: mdl-8227404
ABSTRACT
AIM:
To identify and describe electron microscopic changes occurring in Enterocytozoon bieneusi in patients treated with albendazole.METHODS:
Eighteen HIV seropositive patients with E bieneusi infection of the small intestine were treated with albendazole 400 mg twice a day for one month. Duodenal biopsy specimens obtained before and at the end of treatment were examined electron microscopically by a pathologist who was unaware of the clinical response. A semiquantitative assessment of the parasite load and description of the parasite morphology was made.RESULTS:
A complete resolution of diarrhoea occurred in nine patients and a further three had a greater than 50% reduction in baseline stool frequency or volume. Three of the non-responders were also infected with cryptosporidium. There was a reduction in parasite load in those responding to treatment and an increase in abnormal forms in both responders and non-responders.CONCLUSION:
The clinical response to albendazole treatment seen in some patients with small intestine microsporidiosis may be due to damage to the developmental stages, causing a partial inhibition of parasite reproduction.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Albendazol
/
Microsporida
/
Microsporidiosis
/
Parasitosis Intestinales
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Clin Pathol
Año:
1993
Tipo del documento:
Article