Serum pepsinogen I and II concentrations and IgG antibody to Helicobacter pylori in dyspeptic patients.
J Clin Pathol
; 46(9): 826-8, 1993 Sep.
Article
en En
| MEDLINE
| ID: mdl-8227432
ABSTRACT
AIMS:
To investigate the association between histologically confirmed gastritis, carriage of Helicobacter pylori and pepsinogen (PG) I and PG II concentrations.METHODS:
Prospective study of 81 dyspeptic patients undergoing upper gastrointestinal endoscopy was made. The extent of gastric mucosal inflammation and the presence of H pylori was determined, and serology to evaluate PG I and II concentrations and IgG titres to H pylori was carried out.RESULTS:
The presence of H pylori was strongly correlated with high IgG antibody titres to H pylori and gastritis. Patients who were H pylori positive had significantly higher PG I and PG II concentrations and a significantly lower PG IPG II ratio than patients who were negative for H pylori. In 13 patients with duodenal ulcer and H pylori positive gastritis serum PG I concentrations were significantly higher than in H pylori positive patients without duodenal ulcer. Significant correlations were found between the age of patients and serum PG II, the PG IPG II ratio, IgG antibodies to H pylori, the severity of body gastritis and H pylori infection, and between the degree of gastritis in the body of the stomach and the PG II concentration.CONCLUSIONS:
Serum PG I and II concentrations, together with a fall in the PG IPG II ratio, could be used as predictors of H pylori infection as well as serum IgG antibody response to H pylori.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pepsinógenos
/
Inmunoglobulina G
/
Helicobacter pylori
/
Dispepsia
/
Anticuerpos Antibacterianos
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Clin Pathol
Año:
1993
Tipo del documento:
Article
País de afiliación:
Italia