Your browser doesn't support javascript.
loading
Long-term dietary fish oil supplementation protects against ischemia-reperfusion-induced myocardial dysfunction in isolated rat hearts.
Yang, B C; Saldeen, T G; Bryant, J L; Nichols, W W; Mehta, J L.
Afiliación
  • Yang BC; Department of Medicine, University of Florida, Gainesville.
Am Heart J ; 126(6): 1287-92, 1993 Dec.
Article en En | MEDLINE | ID: mdl-8249783
Dietary fish oil has been shown to exert protective effects against arrhythmias and myocardial infarction after coronary artery occlusion. However, the effects of fish oil on ischemia-reperfusion-induced cardiac dysfunction are not known. This study was designed to examine if long-term dietary fish oil protects against a rise in coronary perfusion pressure and myocardial contractile dysfunction following ischemia and reperfusion. Fifteen Sprague-Dawley rats (age 7 to 9 weeks) were fed fish oil-rich chow for 4 to 5 weeks and 11 rats from the same batch were fed ordinary chow. Three fish oil-fed rats were also fed ad libitum indomethacin for the last 2 days. Isolated hearts from both groups were perfused on a Langendorff apparatus and were subjected to 25 minutes of global ischemia and 20 minutes of reperfusion. Myocardial phospholipid acid content was also measured. After 4 to 5 weeks of dietary fish oil supplementation, myocardial content of long-chain polyunsaturated fatty acid (PUFA) (C20-C22) and omega-3 PUFA was increased and that of omega-6 PUFA was decreased in the fish oil-fed group (all p < 0.01). Following global ischemia and reoxygenation, there was a reduction in the force of cardiac contraction and an increase in coronary perfusion pressure. However, reduction in the force of cardiac contraction was less in the hearts of fish oil-fed rats than in the control hearts (49 +/- 9% vs 63 +/- 5%, p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Asunto(s)
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aceites de Pescado / Daño por Reperfusión Miocárdica / Alimentos Fortificados Límite: Animals Idioma: En Revista: Am Heart J Año: 1993 Tipo del documento: Article Pais de publicación: Estados Unidos
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aceites de Pescado / Daño por Reperfusión Miocárdica / Alimentos Fortificados Límite: Animals Idioma: En Revista: Am Heart J Año: 1993 Tipo del documento: Article Pais de publicación: Estados Unidos