Aqueous acidic degradation of the carbacephalosporin loracarbef.
J Pharm Sci
; 82(10): 1010-7, 1993 Oct.
Article
en En
| MEDLINE
| ID: mdl-8254485
ABSTRACT
The aqueous degradation of the carbacephalosporin loracarbef under moderately acidic conditions (pH range, 2.7-4.3) is described. Structures of a total of 10 compounds isolated by preparative reversed-phase HPLC have been proposed. Five of these 10 degradation compounds arose from hydrolysis of the beta-lactam ring followed by structural changes in the six-membered heterocyclic ring. Four compounds form from intermolecular reactions of loracarbef to form dimeric structures with peptide linkages. The remaining compound resulted from oxidation of the primary amine to a hydroxylamine. Pathways for the formation of these compounds from the parent loracarbef are proposed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cefalosporinas
Idioma:
En
Revista:
J Pharm Sci
Año:
1993
Tipo del documento:
Article