Operating characteristics of 18 different continuous-flow jet nebulizers with beclomethasone dipropionate liposome aerosol.
Chest
; 105(1): 106-10, 1994 Jan.
Article
en En
| MEDLINE
| ID: mdl-8275719
ABSTRACT
A study of 18 different commercially available continuous-flow, jet nebulizers was performed with a standard liposomal formulation of beclomethasone dipropionate (Bec-DP) prepared with dilauroyl phosphatidylcholine (Bec-DLPC). The analysis compared the total Bec-DP output from aqueous suspensions of Bec-DLPC containing an initial starting reservoir concentration of 0.5 mg/ml. Aerosols from each nebulizer tested were characterized by the mass median aerodynamic diameter, geometric standard deviation, drug output, and the predicted percentage regional deposition of inhaled Bec-DLPC liposomes within the human respiratory tract. These data can provide a basis for the selection of commercially available jet nebulizers for use with glucocorticoid liposome aerosols for treatment of asthma and other inflammatory lung diseases.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nebulizadores y Vaporizadores
/
Beclometasona
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Chest
Año:
1994
Tipo del documento:
Article