[The pharmacokinetic and pharmacodynamic characteristics of foridon during interaction with the metabolic oxidation inhibitor dopegit]. / Osobennosti farmakokinetiki i farmakodinamiki foridona pri vzaimodeistvii s ingibitorom metabolicheskogo okisleniia dopegitom.
Eksp Klin Farmakol
; 56(5): 38-41, 1993.
Article
en Ru
| MEDLINE
| ID: mdl-8312808
ABSTRACT
The paper deals with some aspects of the effects produced by dopegite on the pharmacokinetics and pharmacodynamics of foridone from a group of calcium antagonists. Nineteen patients with essential hypertension received a single doses of foridone of 40 mg, then its course therapy in a dose of 90 mg/day for 2 weeks, then it was supplemented with dopegite in a dose of 750 mg/day for 2 weeks too. Supplementation of dopegite caused statistically significant changes as higher plasma concentrations of foridone and increased concentration-time curve areas, decreased total peripheral resistance and regional, and a lower spasm index. Dopegite can be used to enhance the antihypertensive effect of foridone.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bloqueadores de los Canales de Calcio
/
Nifedipino
/
Metildopa
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Revista:
Eksp Klin Farmakol
Asunto de la revista:
FARMACOLOGIA
Año:
1993
Tipo del documento:
Article
Pais de publicación:
FEDERAÇÃO RUSSA
/
RU
/
RUSIA
/
RUSSIA