[Biotransformation and excretion of Z-2-amino-5-chlorobenzophenoneamidinohydrazone]. / Biotransformation und Ausscheidung von Z-2-Amino-5-chlorbenzophenonamidinohydrazon.
Pharmazie
; 48(5): 365-70, 1993 May.
Article
en De
| MEDLINE
| ID: mdl-8327565
ABSTRACT
After i.v., p.o. and i.p. administration of 14C-labeled Z-2-amino-5-chlorobenzophenoneamidinohydrazone (1) to male Wistar rats the total radioactivity is mainly excreted via faeces (80%). Within 3 to 4 d after administration 86 to 100% of the dose have been found in urine and faeces. Beside 1 and its E-isomer (2) we have detected in faeces of rats and rabbits the metabolites 3 (principal metabolite) and 4, in urine of rats additionally 5 and 6, and in urine of rabbits additionally 5 to 8. With regard to the results of high resolution mass spectrometry, UV, TLC and the hydrolyzability using beta-glucuronidase we can conclude that 3 and 4 are metabolites position isomerically hydroxylated at the unsubstituted phenyl group, 5 and 6 are the glucuronides of them, and 7 and 8 are the glucuronides of 1 and 2.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Benzofenonas
/
Hidrazonas
/
Antiarrítmicos
Límite:
Animals
Idioma:
De
Revista:
Pharmazie
Asunto de la revista:
FARMACIA
Año:
1993
Tipo del documento:
Article