Contrasting effects of pyrazinoylguanidine and hydrochlorothiazide in patients with renal insufficiency.
J Clin Pharmacol
; 33(6): 554-61, 1993 Jun.
Article
en En
| MEDLINE
| ID: mdl-8366180
ABSTRACT
A single blind crossover study with washout phases showed that pyrazinoylguanidine (PZG) reduced elevated serum concentrations of urea, triglycerides, and cholesterol in patients with renal insufficiency. Pyrazinoylguanidine was saluretic, without affecting serum potassium or glucose concentrations. The onset of PZG's antihypertensive effect occurred within 4 hours. In contrast, hydrochlorothiazide (HCTZ) increased serum concentrations of urea, triglycerides, and glucose, without affecting cholesterol.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pirazinas
/
Insuficiencia Renal
/
Guanidinas
/
Hidroclorotiazida
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Clin Pharmacol
Año:
1993
Tipo del documento:
Article