Low doses of radiation induce systemic production of cytokines: possible contribution to leukemogenesis.
Int J Cancer
; 55(2): 269-74, 1993 Sep 09.
Article
en En
| MEDLINE
| ID: mdl-8370625
ABSTRACT
Experiments were conducted to explore the possible effect of low-dose irradiation on cytokine production in mice. SJL/J and C57BL/6J mice were exposed to 3 Gy and 4 Gy respectively. At various time intervals thereafter, lung-conditioned media, bone-marrow-conditioned media and sera were collected. Interleukin-6 and macrophage-colony-stimulating-factor activities were tested. Interleukin-6 in lung-conditioned media from both strains was found to be significantly induced by irradiation. Macrophage-colony-stimulating-factor activity was greatly enhanced in sera of irradiated SJL/J mice as well as in bone-marrow-conditioned media of both strains. The kinetics of the radiation-induced interleukin 6 and macrophage-colony-stimulating-factor activity differed in the 2 strains. SJL/J and C57BL/6J mice have been previously shown to be susceptible to low-dose-radiation-induced leukemia. The coleukemogenic effects of both cytokines in 3 different models of experimental leukemogenesis is demonstrated.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leucemia Experimental
/
Transformación Celular Neoplásica
/
Factor Estimulante de Colonias de Macrófagos
/
Interleucina-6
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Int J Cancer
Año:
1993
Tipo del documento:
Article
País de afiliación:
Israel