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Low doses of radiation induce systemic production of cytokines: possible contribution to leukemogenesis.
Tartakovsky, B; Goldstein, O; Krautghamer, R; Haran-Ghera, N.
Afiliación
  • Tartakovsky B; Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.
Int J Cancer ; 55(2): 269-74, 1993 Sep 09.
Article en En | MEDLINE | ID: mdl-8370625
ABSTRACT
Experiments were conducted to explore the possible effect of low-dose irradiation on cytokine production in mice. SJL/J and C57BL/6J mice were exposed to 3 Gy and 4 Gy respectively. At various time intervals thereafter, lung-conditioned media, bone-marrow-conditioned media and sera were collected. Interleukin-6 and macrophage-colony-stimulating-factor activities were tested. Interleukin-6 in lung-conditioned media from both strains was found to be significantly induced by irradiation. Macrophage-colony-stimulating-factor activity was greatly enhanced in sera of irradiated SJL/J mice as well as in bone-marrow-conditioned media of both strains. The kinetics of the radiation-induced interleukin 6 and macrophage-colony-stimulating-factor activity differed in the 2 strains. SJL/J and C57BL/6J mice have been previously shown to be susceptible to low-dose-radiation-induced leukemia. The coleukemogenic effects of both cytokines in 3 different models of experimental leukemogenesis is demonstrated.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Experimental / Transformación Celular Neoplásica / Factor Estimulante de Colonias de Macrófagos / Interleucina-6 Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Int J Cancer Año: 1993 Tipo del documento: Article País de afiliación: Israel
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Experimental / Transformación Celular Neoplásica / Factor Estimulante de Colonias de Macrófagos / Interleucina-6 Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Int J Cancer Año: 1993 Tipo del documento: Article País de afiliación: Israel