Vasectomy, serum assays, and coronary heart disease symptoms and risk factors.
J Clin Epidemiol
; 46(1): 101-9, 1993 Jan.
Article
en En
| MEDLINE
| ID: mdl-8433106
ABSTRACT
PIP: A comparative study of 69 vasectomized and 126 nonvasectomized men enrolled in the Portland (Oregon, US) Center for the Multiple Risk Factor Intervention Trial evaluated vasectomy as a risk factor for cardiovascular disease. In animal studies, atherosclerosis development has been linked to circulating anti-sperm antibodies and immune complexes formed in response to sperm breakdown products released in the body after vasectomy. Vasectomized men smoked more and had lower diastolic and systolic blood pressure than men in the control group. As expected, both sperm immobilization and sperm agglutination assays were significantly higher among vasectomized men than controls; 29.4% of vasectomized men compared with only 2.5% of nonvasectomized men had sperm immobilization values of 0.3 or less, while 54.1% of vasectomized men compared with 12.5% of nonvasectomized men had sperm agglutination values of 20.0 or above. These significant differences persisted even when a variety of coronary heart disease risk factors and treatments were controlled. Multivariate analysis showed that antibody development tended to decrease with age at vasectomy and increase with time since vasectomy. In the case of sperm agglutination, the antibodies clearly increased with time since vasectomy.
Palabras clave
Americas; Antibodies; Antibody Formation; Antigen-antibody Reactions; Biology; Cardiovascular Effects; Comparative Studies; Developed Countries; Diseases; Family Planning; Genitalia; Germ Cells; Heart Diseases; Immunity; Immunologic Factors; Male Sterilization; North America; Northern America; Physiology; Research Methodology; Research Report; Risk Factors; Sperm Agglutination; Spermatozoa; Sterilization, Sexual; Studies; United States; Urogenital System; Vasectomy
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
/
Espermatozoides
/
Vasectomía
/
Enfermedad Coronaria
/
Complejo Antígeno-Anticuerpo
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Clin Epidemiol
Asunto de la revista:
EPIDEMIOLOGIA
Año:
1993
Tipo del documento:
Article