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Kaposi's sarcoma. Epidemiology, pathogenesis, histology, clinical spectrum, staging criteria and therapy.
Tappero, J W; Conant, M A; Wolfe, S F; Berger, T G.
Afiliación
  • Tappero JW; San Francisco General Hospital, California.
J Am Acad Dermatol ; 28(3): 371-95, 1993 Mar.
Article en En | MEDLINE | ID: mdl-8445054
ABSTRACT
The acquired immunodeficiency syndrome (AIDS) epidemic has had a profound impact on our understanding of Kaposi's sarcoma (KS). Epidemiologic features suggest a sexually transmitted cofactor in the pathogenesis of AIDS-associated KS (AIDS-KS), and several putative agents have received intense scrutiny. Cell culture studies suggest that the angiogenesis of AIDS-KS is stimulated by both human immunodeficiency virus proteins and growth factors that may be involved in the development and progression of AIDS-KS, thereby providing a rationale for new therapeutic interventions. The dermatologist is uniquely qualified to provide care for the majority of patients with KS, as many patients have cutaneous lesions amendable to local therapy (cryotherapy, intralesional therapy, simple excision). Patients requiring more aggressive local therapy (radiation therapy) or systemic therapies (interferon, chemotherapy) can be easily recognized. Standardized staging criteria provide assistance for determining appropriate local or systemic therapy and for evaluating and comparing responses to new therapies. This article reviews the epidemiology, pathogenesis, histologic features, clinical spectrum, staging criteria, and treatment of KS.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcoma de Kaposi Tipo de estudio: Etiology_studies / Screening_studies Límite: Humans Idioma: En Revista: J Am Acad Dermatol Año: 1993 Tipo del documento: Article
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcoma de Kaposi Tipo de estudio: Etiology_studies / Screening_studies Límite: Humans Idioma: En Revista: J Am Acad Dermatol Año: 1993 Tipo del documento: Article