Septohippocampal cholinergic changes after destruction of the A10-septal dopaminergic pathways.
Neuropharmacology
; 32(2): 113-7, 1993 Feb.
Article
en En
| MEDLINE
| ID: mdl-8450940
ABSTRACT
Mice were injected bilaterally into the septum with 6-hydroxydopamine and 6 weeks later the hippocampi were assayed for activity of choline acetyltransferase, muscarinic receptor binding capabilities and for formation of inositol phosphate in response to direct (carbachol) or presynaptically elicited (K+) stimulation of the postsynaptic receptors. Levels of dopamine in the septum were reduced by 70% in the lesioned animals and hippocampal choline acetyltransferase was elevated by the same amount. The Bmax of muscarinic binding was significantly reduced without changes in Kd; nevertheless, carbachol-induced stimulation of formation of inositol phosphate was unaffected. The response to K+ was markedly elevated in the 6-hydroxydopamine-treated animals. Thus, the regulatory effect of A10-septal dopaminergic pathways on the septohippocampal cholinergic innervations is both on the presynaptic and postsynaptic levels.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sistema Nervioso Parasimpático
/
Encéfalo
/
Dopamina
/
Hipocampo
Límite:
Animals
Idioma:
En
Revista:
Neuropharmacology
Año:
1993
Tipo del documento:
Article
País de afiliación:
Israel